AMPA receptor subunit GluR 1 ( GluA 1 ) serine - 845 site is involved in synaptic 2 depression but not in spine shrinkage associated with chemical long - term 3 depression
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چکیده
1 1 AMPA receptor subunit GluR1 (GluA1) serine-845 site is involved in synaptic 2 depression but not in spine shrinkage associated with chemical long-term 3 depression 4 5 Kaiwen He, Angela Lee, Lihua Song, Patrick O. Kanold, and Hey-Kyoung Lee 6 7 1. Department of Biology, University of Maryland, College Park, MD 20742. 8 2. Neuroscience and Cognitive Science (NACS) Program, University of Maryland, 9 College Park, MD 20742. 10 11 Corresponding author: Hey-Kyoung Lee 12 Department of Biology, 13 University of Maryland, 14 College Park, MD 20742 15 (Tel.) 301-405-9784 16 (Email) [email protected] 17 18 19 Running title: Morphological and functional changes following chemLTD 20 21 22 23 Articles in PresS. J Neurophysiol (February 9, 2011). doi:10.1152/jn.00913.2010
منابع مشابه
AMPA receptor subunit GluR1 (GluA1) serine-845 site is involved in synaptic depression but not in spine shrinkage associated with chemical long-term depression.
The structure of dendritic spines is highly plastic and can be modified by neuronal activity. In addition, there is evidence that spine head size correlates with the synaptic α-amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) receptor (AMPAR) content, which suggests that they may be coregulated. Although there is evidence that there are overlapping mechanisms for structural and functiona...
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Activity-dependent changes in excitatory synaptic transmission in the CNS have been shown to depend on the regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1, also referred to as GluA1 or GluR-A) plays a role in long-term potentia...
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Physiological and morphological alterations occur with long-term synaptic modifications, such as long-term potentiation (LTP) and long-term depression (LTD), but whether these two processes are independent or interactive is unclear. It is also unknown whether or how morphological modifications, like spine remodeling, may contribute to physiological modifications, such as trafficking of glutamat...
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تاریخ انتشار 2011